Related information

by Forte, G.I. et al.
Gruppo di studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università Palermo, Palermo, Italy

These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS.
Rejuvenation. Res. 2007; 3:293-9

[See paper]